Senior/Principal Scientist
Our client, an emerging, venture-backed biotech company developing RNAi genetic therapies gearing up for aggressive growth, is looking for a Senior/Principal Scientist to join their Chemistry team as both a leader and an innovator. This person will provide scientific strategy and leadership for novel technology’s formulation, manufacture and process development to drive rapid advancement of candidate selection.
Responsibilities:
- Drive and lead the conditionally activated siRNA technology and platform to support RNA-based therapeutics, working in collaboration with partners in Neuroscience, Biology, Foundation Research and Bioinformatics.
- Provide scientific strategy, and leadership for novel manufacture platform and process development with the formulation, for in vivo delivery of siRNA, and other therapeutic modalities.
- Guide junior scientists with the implementation of decisive experiments to identify best-in-class designs, ligands, and formulations to drive rapid advancement of candidate selection.
- Participate in portfolio and stage-gate reviews, lead the preparation and presentation of dossiers for clinical candidate nomination and compound advancement.
- Manage third-party CRO and CMOs for collaboration and outsourced work as needed.
- Critically evaluate experiment data and communicate scientific findings as verbal presentations and written reports; and provide updates on project status to Discovery leadership Teams.
Qualifications:
- PhD degree in synthetic organic chemistry, medicinal chemistry, analytical chemistry, or related scientific discipline, preferably related to oligonucleotides is required.
- Postdoctoral experience with an emphasis on nucleic acid chemistry, purification and annealing strategies of siRNA is preferred.
- Multiple years of experience in the biopharmaceutical industry with a proven track record of leading innovative oligonucleotide discovery projects is strongly preferred.
- Demonstrated experience as a project leader and managing teams in a biopharmaceutical or biotech industry preferred.
- Strong track record of scientific contributions including peer reviewed publications, patent applications, and/or presentations at major national meetings is preferred.
- Ability to collaborate across teams in a matrix environment is required.
- A deep commitment to working as part of teams to deliver breakthrough medicines.
- Excellent communication, organization, and time management skills and ability to work both independently and collaboratively
The pay range for this position at commencement of employment is expected to be between $120,000 and $150,000 per year; however, base pay offered may vary depending on individualized factors, including market location, job-related knowledge, skills, and experience. The total compensation package for this position may also include other elements, including equity in the Company, a discretionary annual bonus, in addition to a full range of healthcare,
financial, and/or other benefits (including 401(k) eligibility and various paid time off benefits such as vacation, sick time, and parental leave. Details of participation in these benefit plans will be provided if a candidate receives an offer of employment.
If you are interested in this position, please send your resume to [email protected]
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